What is Palo Santo? Palo Santo (Bursera Graveolens) is a sacred tree and grows in select parts of South America. Translated from Spanish, Palo Santo means Wood of the Saints or Sacred Wood. It has been used for many centuries by shamans in ritual prayer, ceremonies and healing. Like its close botanical cousins, Frankincense and Myrrh, it is rich in brain-oxygenating terpenes such as limonene and a-terpineol which give the Palo its uplifting and positive qualities.